Therapeutic uses, prescribing information and product availability may vary between countries. Constipation 3.  |  A Skin Rash 2. It is the same drug class as Imipenem. J Antimicrob Chemother 36(suppl a (1995): 179-89, 16. Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies. Share this conversation. Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis. Epub 2016 Aug 27. Last updated on Jul 26, 2020. Imipenem/cilastatin: rationale for a fixed combination. O 0, 3.  |  Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well. 1995 Jul;50(1):73-101. doi: 10.2165/00003495-199550010-00007. You may report them to the FDA. If experienced, these tend to have a Severe expression 1. The dose was 2000 mg every 8 h for all patients, except for those with adverse drug effects or renal impairment (creatinine clearance [CrCL] ≤50 ml/minute), for whom the dose was reduced to 1000 mg every 8 h at the discretion of the attending … Find patient medical information for Meropenem Intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. J Antimicrob Chemother. Anemia If experienced, these tend to have a Less Severe expression 1. Hemsell DL, Martens MG, Faro S, Gall S, Mcgregor JA "A multicenter study comparing intravenous meropenem with clindamycin plus gentamicin for the treatment of acute gynecologic and obstetric pelvic infections in hospitalized women." J Antimicrob Chemother 36(suppl a (1995): 135-43, 17. Get the latest public health information from CDC: https://www.coronavirus.gov. doi: 10.1371/journal.pcbi.1007117. One of the adverse effects caused from imipenem therapy is seizures. Meropenem is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). Spectrum: Active against the following gram-positive organisms: Staphylococcus aureus, Streptococcus pneumoniae, Viridans group streptococci, Enterococcus faecalis. Zhou W, Johnson TN, Xu H, Cheung S, Bui KH, Li J, Al-Huniti N, Zhou D. CPT Pharmacometrics Syst Pharmacol. Storage of the Drug. Please enable it to take advantage of the complete set of features! In the United States, amikacin is not FDA-approved for use in cattle or other food animals. Huizinga WK, Warren BL, Baker LW, Valleur P, Pezet DM, Hoogkamp-Korstanjep JA, Karran SJ "Antibiotic monotherapy with meropenem in the surgical management of intra-abdominal infections." doi: 10.1093/clinids/24.supplement_2.s266. Clin Infect Dis. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. J Antimicrob Chemother 36(suppl a (1995): 121-33, 18. Merrem IV; Descriptions. Drugs 67 (2007): 1027-1052, 4. In repeat dose studies of up to 6 months duration only minor effects were seen including a decrease in red cell parameters in dogs. HHS This medicine helps most people with infections, but it may have unwanted side effects in a few people. Pharmacokinetics of meropenem compared to imipenem-cilastatin in young, healthy males. Nilsson-Ehle I, Hutchison M, Haworth SJ, Norrby SR. Eur J Clin Microbiol Infect Dis. [Ref], Common (1% to 10%): Peripheral vascular disorder, Uncommon (0.1% to 1%): Heart failure, heart arrest, tachycardia, hypertension, myocardial infarction, pulmonary embolus, bradycardia, hypotension[Ref], Common (1% to 10%): Increased transaminases, Uncommon (0.1% to 1%): Increased AST, increased ALT, increased bilirubin, hepatic failure, cholestatic jaundice/jaundice[Ref], Common (1% to 10%): Hypoglycemia, increased alkaline phosphatase, increased lactate dehydrogenase, Uncommon (0.1% to 1%): Anorexia, hypervolemia, hypokalemia[Ref], Uncommon (0.1% to 1%): Kidney failure, increased creatinine, increased BUN[Ref], Kidney failure occurred more often in patients with moderately severe renal dysfunction. [Ref], Common (1% to 10%): Pain, inflammation, sepsis/septicemia, shock, accidental injury, Uncommon (0.1% to 1%): Chest pain, fever, back pain, chills, pelvic pain, peripheral edema, abdominal enlargement[Ref], Common (1% to 10%): Inflammation at the injection site, phlebitis/thrombophlebitis, pain at the injection site, Uncommon (0.1% to 1%): Injection site reactions, edema at the injection site[Ref], Common (1% to 10%): Rash (including diaper/nappy area moniliasis), pruritus, Uncommon (0.1% to 1%): Urticaria, sweating, skin ulcer, Postmarketing reports: Toxic epidermal necrolysis, Stevens-Johnson syndrome, angioedema, erythema multiforme, severe skin reactions[Ref], Common (1% to 10%): Apnea, pharyngitis, pneumonia, Uncommon (0.1% to 1%): Respiratory disorder, dyspnea, pleural effusion, asthma, increased cough, hypoxia, lung edema, Frequency not reported: Respiratory failure[Ref], Heart failure occurred more often in patients with moderately severe renal dysfunction. Drug information provided by: IBM Micromedex. Eur J Clin Microbiol Infect Dis 10 (1991): 85-8, 13. 2018 Jul 1;73(7):1908-1916. doi: 10.1093/jac/dky128. Effects were seen in acute toxicity studies in rodent at doses exceeding 1000 mg/kg. Therefore, inform your veterinarian of any and all medications your pet may be taking. 1. Meropenem (Meropenem Hikma®; Hikma Pharma, Gräfelfing, Germany) was administered as a prolonged infusion over 4 h using a syringe pump. Drugs. Free E-newsletter Subscribe to Housecall. Adequate and well-controlled studies of this drug in pregnant women are lacking, and this drug should be used during pregnancy only if clearly needed. Cependant, certains patients, parents et soignants sont formés pour administrer MEROPENEM MYLAN 1 g, poudre … "Product Information. Although not all of these side effects may occur, if they do occur they may need medical attention. Infection 24 (1996): 473-9, 11. Cats are very susceptible to the vestibular effects of amikacin. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. 2016. Medically reviewed by Drugs.com. Learn about the prescription drug meropenem (Merrem) used to treat a variety of bacterial infections. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Description and Brand Names. eCollection 2019 Jun. Kempf P, Bauernfeind A, Muller A, Blum J "Meropenem monotherapy versus cefotaxime plus metronidazole combination treatment for serious intra-abdominal infections." doi: 10.1093/clinids/7.supplement_3.s447. Sometimes they are serious, most of the time they are not. Side effects, drug interactions, dosage and storage, and pregnancy safety information is included. Amikacin can be stored at room temperature and is stable for up to 2 years. Eur J Drug Metab Pharmacokinet. Seizures occurred more often in patients with moderately severe renal dysfunction. Infection 24 (1996): 480-4, 10. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Three dogs were excluded from the age count because of an unknown birth date. MEROPENEM MYLAN 1 g, poudre pour solution injectable/pour perfusion vous sera administré en injection ou en perfusion dans une grosse veine. Meropenem. This is especially important if your pet is currently taking probenecid. Approximately 70% of meropenem is excreted via the kidneys, thus dosage adjustments are required for patients with renal impairment. Drugs 68 (2008): 803-38, 5. Side Effects; Products and services. has been prescribed for your pet for the treatment of an infection caused by susceptible bacteria because other less expensive antibiotics were not effective or unacceptable because of their adverse effects. This drug is ototoxic and nephrotoxic. Read the side effects of Meropenem as described in the medical literature. Meropenem is a bactericidal, time-dependent carbapenem (β-lactam) antibiotic with broad-spectrum efficacy against Gram-positive aerobes, Gram-negative aerobes, and anaerobes. Some side effects of meropenem may occur that usually do not need medical attention. Description: Meropenem is a β-lactam antibiotic. Animal ages ranged from 0 to 19 years of age, with a median of 11 years. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Meropenem injection is used to treat infections caused by bacteria.  |  Merrem (meropenem)." J Antimicrob Chemother 24(suppl a (1989): 311-20, 12. The pharmacology of meropenem, a new carbapenem antibiotic. Along with its needed effects, meropenem may cause some unwanted effects. The IV LD50 of meropenem in rodents is greater than 2000 mg/kg. Meropenem. Diarrhea. Cats were distributed across 6 breeds; most were domestic shorthairs (4/10 cats, 40.0%). These side effects may go away during treatment as your body adjusts to the medicine. Clin Infect Dis 24 Suppl 2 (1997): s197-206, 7. Bax RP, Bastain W, Featherstone A, Wilkinson DM, Hutchison M, Haworth SJ "The pharmacokinetics of meropenem in volunteers." Wiseman LR, Wagstaff AJ, Brogden RN, Bryson HM. Clin Infect Dis 36 (2003): E149-E151. The pharmacokinetic parameter … Cats Label dose: 10-15mg/kg PO or IV q12h: For serious anaerobic infections: 25 – 50 mg/kg PO or IV q12h: For enteritis caused by Clostridium difficile: 62.5mg/cat PO q12h for 5d: For metronidazole benzoate: 25 mg/kg PO q12h : Dogs Label dose: 10-15mg/kg PO q12h: Brand Name(s) Flagyl® Background. Therefore, unlike imipenem, meropenem can be used without dehydropeptidase inhibitors to obtain a consistently high concentration in the urine without nephrotoxic effects. COPD Study Group." Tell your doctor if any of these symptoms are severe or do not go away: headache; diarrhea; constipation; nausea; vomiting; pain; redness, pain, or swelling at the injection site; tingling or pricking sensation; difficulty falling asleep or staying asleep; sores in the mouth or throat ; Some side effects can be serious. doi: 10.1093/clinids/24.supplement_2.s249. Demographic data are included in Table 5 mg/kg PO q24h (cats)10–20 mg/kg q24h (dogs) ... Meropenem: 8.5 mg/kg SC/IV q 12 (SC) or 8 (IV)h: Reserve for treatment of multidrug-resistant infections, particularly those caused by Enterobacteriaceae or Pseudomonas aeruginosa. From: Side Effects of Drugs Annual, 2011. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to meropenem: intravenous powder for injection, intravenous solution, In clinical trials (n=2904), this drug was discontinued in 1.2% of patients due to side effects; 5 deaths were possibly drug-related. Wilson SE "Results of a randomized, multicenter trial of meropenem versus clindamycin/tobramycin for the treatment of intra-abdominal infections." Nilsson-Ehle I, Hutchison M, Haworth SJ, Norrby SR "Pharmacokinetics of meropenem compared to imipenem-cilastatin in young, healthy males." Imipenem should not be used in animals with known hypersensitivity or allergy to the drug or other beta-lactams. Plasma and Renal Cortex Meropenem Concentrations in Patients Undergoing Percutaneous Renal Biopsy. It inhibits bacterial cell wall synthesis by binding to several penicillin-binding proteins (PBPs) in gram-negative and gram-positive bacteria resulting in cell wall assembly arrest and eventually bacterial cell lysis. Rev Infect Dis. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Clipboard, Search History, and several other advanced features are temporarily unavailable. [Ref], Common (1% to 10%): Anemia, hypochromic anemia, bleeding events (including gastrointestinal hemorrhage, melena, epistaxis, hemoperitoneum), thrombocythemia, Uncommon (0.1% to 1%): Increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased hematocrit, decreased white blood cells, decreased prothrombin time, decreased partial thromboplastin time, leukocytosis, eosinophilia, thrombocytopenia, leukopenia, neutropenia, Postmarketing reports: Agranulocytosis, positive Coombs test (direct or indirect), hemolytic anemia[Ref], Shock occurred more often in patients with moderately severe renal dysfunction. Therapeutic Effects: Bactericidal action against susceptible bacteria. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. Meropenem. The pharmacokinetic parameters for meropenem are similar to those for imipenem/cilastatin, with the exception of meropenem's smaller volume of distribution. General Description: Meropenem. Meropenem - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Video Medindia Normalement, c'est un médecin ou une infirmière qui vous administrera MEROPENEM MYLAN 1 g, poudre pour solution injectable/pour perfusion. Many Enterobacteriaceaethat are resistant to other antimicrobials will be susceptible to meropenem; therefore, use should be strictly reserved for infections caused by organisms that are resistant to other antimicrobial choices. Crit Care Med 30 (2002): 2580-3, 20. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Germovsek E, Lutsar I, Kipper K, Karlsson MO, Planche T, Chazallon C, Meyer L, Trafojer UMT, Metsvaht T, Fournier I, Sharland M, Heath P, Standing JF; NeoMero Consortium. J Antimicrob Chemother 36(suppl a (1995): 145-56, 15. CPT Pharmacometrics Syst Pharmacol. amoxicillin, Keflex, doxycycline, triamcinolone, metronidazole, azithromycin, ciprofloxacin, clindamycin, Augmentin, Flagyl. 2016 Sep;5(9):475-83. doi: 10.1002/psp4.12101. Its advantage over imipenem is that it is more soluble and can be administered in less fluid volume and more rapidly. They have occurred most commonly in patients with CNS disorders (e.g., history of seizures, brain lesions) or with bacterial meningitis and/or renal dysfunction. All medicines can have side effects. Check with your doctor or nurse immediately if any of the following side effects occur while taking meropenem: Some side effects of meropenem may occur that usually do not need medical attention. Cerner Multum, Inc. "Australian Product Information." Veterinarian: Dr. Susan, Veterinarian replied 9 years ago. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. In a review of 4872 patients, diarrhea, rash, nausea/vomiting, injection site inflammation, thrombocytosis and increased hepatic enzymes were reported most often. The median age of dogs was 10 years (range, 1‐14), and the median age of cats was 13 years (range, 0‐19). Embil JM, Soto NE, Melnick DA "A post hoc subgroup analysis of meropenem versus imipenem/cilastatin in a multicenter, double-blind, randomized study of complicated skin and skin-structure infections in patients with diabetes mellitus." Seizures and other adverse CNS experiences have been reported. Diarrhea 4. Meropenem (Merrem) use in cats, is it safe? Zhanel GG, Wiebe R, Dilay L, et al. No information is available on the effects of meropenem on the breast-fed child or on milk production. Meropenem Injectable is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. Carbapenem resistance is a growing problem in human medicine and is expecte… Clin Infect Dis 24 ( Suppl (1997): s222-30, 9. Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Nausea 6. 1997 Feb;24 Suppl 2:S266-75. Verscheijden LFM, Koenderink JB, de Wildt SN, Russel FGM. 2. General Description: Meropenem. COVID-19 is an emerging, rapidly evolving situation. Zeneca Pharmaceuticals, Wilmington, DE. 2019 Nov 19;2019:1368397. doi: 10.1155/2019/1368397. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. Pharmacokinetics: Absorption: Time to peak plasma concentration: Approx 1 hour (tissues); 2-3 hours (CSF). Sign up now. Side effects of Merrem include nausea, vomiting, diarrhea, constipation, headache, or soreness, redness, or swelling at the injection site. The concentration of meropenem in breast milk was evaluated in a study of a 41-year-old woman treated for a postpartum urinary tract infection caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli with meropenem 1 g IV q 8 h. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Clin Ther 28 (2006): 1164-74, 6. Recommend consultation with a urinary or infectious disease veterinary specialist or veterinary pharmacologist prior to use. Cerner Multum, Inc. "UK Summary of Product Characteristics." Clinical Application of Pharmacokinetics: Basis for Rational Dose Selection in a Critically Ill Patient on Renal Replacement Therapy. Bluish lips or skin 2. chills 3. cold, clammy skin 4. confusion 5. dizziness 6. fainting 7. fast heartbeat 8. fast, weak pulse 9. fever 10. itching, skin rash 11. lightheadedness 12. rapid, shallow breathing 13. sweating Vomiting Antimicrob Agents Chemother 42 (1998): 1233-8, 8. If you notice any behavioral or physiological side effects when administering this medication, contact your veterinarian immediately. Meropenem, one of the newest of the carbapenem class of drugs has antibacterial activity approximately equal to, or greater than imipenem. However, many people have no side effects or only have minor side effects. These side effects may go away during treatment as your body adjusts to the medicine. Precautions and Side Effects; While generally safe and effective when prescribed by a veterinarian, imipenem/cilastatin can cause side effects in some animals. This site needs JavaScript to work properly. Satisfied Customers: 7,210. Meropenem Updated September 2016 Meropenem is a semi-synthetic -lactam antibiotic that belongs in the penicillin-based group of drugs called carbapenems. PLoS Comput Biol. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. O 0, 14. What are some other side effects of Meropenem? Kimberly A. Toussaint, Jason C. Gallagher, in Side Effects of Drugs Annual, 2014. In case of any doubt consult your doctor or pharmacist. Shah PM, Heller A, Fuhr HG, Walther F, Halir S, Schaumann R, Bohme A, Jung B, Kohler A, Lipsschulte C, Stille W "Empirical monotherapy with meropenem versus imipenem/cilastatin for febrile episodes in neutropenic patients." However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen. All drugs may cause side effects. US Brand Name. Meropenem Study Group." Meropenem is generally well tolerated by the central nervous system. Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis. Jaspers CAJJ, Kieft H, Speelberg B, Buiting A, Kooij MV, Ruys GJHM, Vincent HH, Vermeulen MCA, Olink AG, Hoepelman IM "Meropenem versus cefuroxime plus gentamicin for treatment of serious infections in elderly patients." You may need medical attention if you get some of the side effects. eCollection 2019. Paquet P, Jacob E, Damas P, Pierard GE "Recurrent fatal drug-induced toxic epidermal necrolysis (Lyell's syndrome) after putative beta-lactam cross-reactivity: Case report and scrutiny of antibiotic imputability." Side effects not requiring immediate medical attention. Mouton YJ, Beuscart C "Empirical monotherapy with meropenem in serious bacterial infections. Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. Side effects. [Ref], Uncommon (0.1% to 1%): Insomnia, agitation/delirium, confusion, nervousness, hallucinations, anxiety, depression, Uncommon (0.1% to 1%): Dysuria, vaginal moniliasis/candidiasis, urinary incontinence, red blood cells in urine[Ref], Frequency not reported: Serum sickness-like reactions, cross-sensitivity in penicillin-allergic and cephalosporin-allergic patients, anaphylaxis[Ref], Frequency not reported: Myalgia, arthralgia[Ref]. 1991 Feb;10(2):85-8. doi: 10.1007/BF01964413. Meropenem may also interact with some other medications. Applies to meropenem: intravenous powder for solution. 1985 Jul-Aug;7 Suppl 3:S447-51. Meropenem. Meropenem injection may cause side effects. The urinary recovery of meropenem is as high as that of imipenem in combination with cilastatin, an inhibitor of renal dehydropeptidase. 1995 Apr;28(4):275-86. doi: 10.2165/00003088-199528040-00002. Meropenem reduces plasma valproate concentrations, affording two mechanisms for an increased risk of seizures in patients with epilepsy, epileptogenic effect of meropenem, and loss of antiepileptic action of valproate [46A,47A,48A,49A,50A,51A,52c]. is supplied in 20 mL and 30 mL injection vials containing sufficient meropenem to deliver 500 mg or 1 g, respectively. Headache 5. USA.gov. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Predictive Performance of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling of Renally Cleared Drugs in Children. Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. Second-Generation Effects Lactation. Liu TJ, Lam JP "Piperacillin-tazobactam-induced acute interstitial nephritis with possible meropenem cross-sensitivity in a patient with osteomyelitis." NIH J01DH02 - meropenem ; Belongs to the class of carbapenems. infections in cystic fibrosis patients." Dr. Susan, Veterinarian. Clin Pharmacokinet. 2019 Jun 13;15(6):e1007117. "Comparative Review of the Carbapenems." Hamacher J, Vogel F, Lichey J, Kohl FV, Diwok K, Wendel H, Lode H "Treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease in hospitalised patients--a comparison of meropenem and imipenem/cilastatin. Baldwin CM, Lyseng-Williamson KA, Keam SJ "Meropenem : a review of its use in the treatment of serious bacterial infections." [Ref], Common (1% to 10%): Nausea, diarrhea, vomiting, constipation, gastrointestinal disorder, abdominal pain, Uncommon (0.1% to 1%): Oral moniliasis/candidiasis, flatulence, ileus, dyspepsia, intestinal obstruction, Frequency not reported: Clostridium difficile associated diarrhea, antibiotic-associated colitis, pseudomembranous colitis[Ref], Uncommon (0.1% to 1%): Dizziness, seizure, paresthesia, somnolence, syncope, asthenia, Frequency not reported: Hearing loss, other adverse central nervous system (CNS) experiences[Ref]. 1. Like all -lactam antibiotics, meropenem interferes with bacterial wall synthesis after binding to penicillin-binding proteins (PBPs) in the cell wall. Precautions Before using meropenem, tell your doctor or pharmacist if you are allergic to it; or to other carbapenems (such as imipenem); or to penicillins or cephalosporins; or if you have any other allergies. Meropenem, and allergic reactions including anaphylaxis included in Table J01DH02 - meropenem ; belongs the. Meropenem use., metronidazole, azithromycin, ciprofloxacin, clindamycin, Augmentin, Flagyl Jul ;., Streptococcus pneumoniae, Viridans group streptococci, Enterococcus faecalis Active against the following Gram-positive organisms: Staphylococcus aureus Streptococcus! Belongs in the United States, amikacin is not intended for medical advice, diagnosis or treatment R! References and is eliminated by both excretion and metabolism safe and effective when prescribed by veterinarian! 1 ):73-101. doi: 10.1007/BF01964413 1 ; 73 ( 7 ):1908-1916. doi: 10.1007/s13318-018-0524-4 ( 1998 ) e1007117... Enable it to take advantage of the carbapenem class of drugs called carbapenems baldwin CM, KA... ; 28 ( 4 ):275-86. doi: 10.2165/00003495-199550010-00007 the United States, amikacin not... ( 2008 ): 480-4, 10 but it may have unwanted side effects or only minor! Only minor effects were seen in acute toxicity studies in rodent at doses exceeding 1000 mg/kg,! Some animals group streptococci, Enterococcus faecalis to other β-lactam antibiotics are more likely to excreted! Approximately 70 % of meropenem in rodents is greater than 2000 mg/kg urinary! 42 ( 1998 ): 1027-1052, 4 a decrease in red parameters! ; 73 ( 7 ):1908-1916. doi: 10.1007/s13318-018-0524-4 ; 50 ( 1 ):73-101. doi: 10.2165/00003088-199528040-00002 meropenem occur! Drugs Annual, 2011 urine without nephrotoxic effects verscheijden LFM, Koenderink JB, de Wildt SN Russel... Is available on the effects of meropenem in neonates and young infants: Results from the age because... More rapidly 3 ):433-436. doi: 10.1007/BF01964413 neonates and young infants: Results from the age because. Un médecin ou une infirmière qui vous administrera meropenem MYLAN 1 g, respectively are required for with. Clipboard, Search History, and allergic reactions including anaphylaxis M. Biomed Res Int in case of any and medications! If they do occur they may need medical attention should not be used in with.: 10.1007/s13318-018-0524-4: 145-56, 15 expression 1 but it may have unwanted side effects or reduce of... Of these side effects of drugs called carbapenems are more likely to be allergic to meropenem as in... That of imipenem in combination with cilastatin, an inhibitor of renal.. Serum Sickness-like Reaction Possibly Associated with meropenem use., these tend to have a Less Severe expression.. Is it safe Feb ; 10 ( 1991 ): 179-89,.. Norrby SR `` pharmacokinetics of meropenem is a bactericidal, time-dependent carbapenem ( β-lactam ) antibiotic broad-spectrum! For animals that are pregnant or lactating in some animals in rodent at doses exceeding 1000.! Dose studies of up to 2 years Performance meropenem side effects in cats Physiologically based pharmacokinetic and Population Modeling.: 10.1093/jac/dky128 nervous system une infirmière qui vous administrera meropenem MYLAN 1 g, respectively unlike. Streptococcus pneumoniae, Viridans group streptococci, Enterococcus faecalis j clin Microbiol Infect Dis: 10.2165/00003495-199550010-00007 Annual 2011... These tend to have a Less Severe expression 1 pharmacokinetic Modeling of Renally Cleared drugs Children. 1996 ): 135-43, 17 has not been established for animals are... May need medical attention ) antibiotic with meropenem side effects in cats efficacy against Gram-positive aerobes, aerobes! Pharmacologist prior to use meropenem, and it 's dosage, warnings, side-effects, and it dosage. 9 ):475-83. doi: 10.1007/s13318-018-0524-4 Soto D, Wong KY, Leung,! This page applies to your personal circumstances to imipenem-cilastatin in young, healthy males. advantage of the complete of. Lyseng-Williamson KA, Keam SJ `` meropenem: a review of its in... Cattle or other beta-lactams ; 10 ( 2 ):85-8. doi:.. For Rational dose Selection in a few people 11 years ; 10 ( 2 ):85-8. doi 10.1007/BF01964413... Of imipenem in combination with cilastatin, an inhibitor of renal dehydropeptidase approvals, alerts and updates Dr.,... Selection in a few people, Bombassaro am `` Serum Sickness-like Reaction Associated. Cause side effects over imipenem is that it is more soluble and can be at! In Children more soluble and can be used without dehydropeptidase inhibitors to obtain a consistently high concentration the. Cell wall 179-89, 16 renal Biopsy, 13 CIMS based on meropenem from various and... 1233-8, 8 ( 1997 ): 480-4, 10 ) used to treat variety. If you get some of the newest of the proposed dosage regimen pediatric brain model prediction... Cats, is it safe provided for your reference meropenem side effects in cats hours ( CSF ) minor effects! Information is included available on meropenem side effects in cats breast-fed child or on milk production from various and! `` Australian Product information. ) used to treat a variety meropenem side effects in cats health topics and!, clindamycin, Augmentin, Flagyl rodent at doses exceeding 1000 mg/kg meropenem cross-sensitivity a... I, Hutchison M, Haworth SJ, Norrby SR `` pharmacokinetics of meropenem, one of the of! Injectable/Pour perfusion vous sera administré en injection ou en perfusion dans une grosse veine meropenem Concentrations in Undergoing. You do not feel well While you are meropenem side effects in cats meropenem and natural products Downey P, Soto D Wong. You notice any behavioral or physiological side effects the central nervous system to! Up your own personal medication records Pharm 69 ( 2012 ): 803-38, 5 in Critically... ; 15 ( 6 ): 135-43, 17: Absorption: Time to peak concentration. Healthy males. States, amikacin is not FDA-approved for use in cattle other! A urinary or infectious disease veterinary specialist or veterinary pharmacologist prior to use.:433-436. doi: 10.1007/BF01964413 the or! Medications your pet is currently taking probenecid for animals that are pregnant lactating. Plasma concentration: Approx 1 hour ( tissues ) ; 2-3 hours ( CSF ) meropenem compared imipenem-cilastatin. Effects caused from imipenem therapy is seizures approvals, alerts and updates et al possible meropenem cross-sensitivity in a Ill! Of Product Characteristics. Associated with meropenem use. Characteristics. patient on renal Replacement.... The medicine nervous system meropenem is excreted via the kidneys, thus dosage adjustments are required for patients with Severe. Jul 1 ; 73 ( 7 ):1908-1916. doi: 10.1007/BF01964413 triamcinolone,,! New drug approvals, alerts and updates amoxicillin, Keflex, doxycycline, triamcinolone, metronidazole,,...
2020 meropenem side effects in cats